| Smith, Will |
Oscar (voice) |
| De Niro, Robert |
Don Lino (voice) |
| Zellweger, Renée |
Angie (voice) |
| Black, Jack |
Lenny (voice) |
| Jolie, Angelina |
Lola (voice) |
| Scorsese, Martin |
Sykes (voice) |
| Marley, Ziggy |
Ernie (voice) |
| Doug, Doug E. |
Bernie (voice) |
| Imperioli, Michael |
Frankie (voice) |
| Pastore, Vincent |
Luca (voice) |
| Falk, Peter |
Don Feinberg (voice) |
| Couric, Katie |
Katie Current (voice) |
| Soren, David |
Shrimp/Worm/Starfish #1/Killer Whale #2 (voice) |
| Smith, David P. |
Crazy Joe (voice) |
| Thompson, Bobb'e J. |
Shortie #1 (voice) |
| Minter, Kamali |
Shortie #2 (voice) |
| Segan, Emily Lyon |
Shortie #3 (voice) |
| Venito, Lenny |
Giuseppe/Great White #1 (voice) |
| Guerra, Saverio |
Pontrelli (voice) |
| Morrison, Shelley |
Mrs. Sanchez (voice) |
| Swift, Mark |
Announcer (voice) |
| Madio, James |
Great White #2/Hammerhead (voice) |
| Vincent, Frank |
Great White #3 (voice) |
| Siravo, Joseph |
Great White #5 (voice) |
| Alterman, Steve |
Messenger Fish/Tip Fish #2 (voice) |
| LaMarr, Phil |
Prawn Shop Owner (voice) |
| Lewis, Jenifer |
Motown Turtle (voice) |
| Bishop, Sean |
Tip Fish #1/Great White #4/Whale/Killer Whale #1 (voice) |
| Ryan, James |
Cashier/Starfish #2 and 3/Oyster/Clown Whale (voice) |
| Ouaou, Latifa |
Whale Wash Co-Worker (voice) |
| Yanover, David |
Taxi Fish (voice) |
| Dorff, Holly |
Adr voice |
| Mangat, Faiz-Kevin |
Ernie |
| Phillips, Fiona |
Katie Current (UK version of film) |
| Aguilera, Christina |
Christina (voice) (uncredited) |
| Elliott, Missy 'Misdemeanor' |
Missy (voice) (uncredited) |
