| Snipes, Wesley |
Blade/Eric Brooks/'The Daywalker' |
| Dorff, Stephen |
Deacon Frost |
| Kristofferson, Kris |
Abraham Whistler |
| Wright, N'Bushe |
Dr. Karen Jenson |
| Logue, Donal |
Quinn |
| Kier, Udo |
Vampire Elder Dragonetti |
| Jover, Arly |
Mercury |
| Lords, Traci |
Racquel |
| Walls, Kevin Patrick |
Officer Krieger |
| Guinee, Tim |
Dr. Curtis Webb |
| Lathan, Sanaa |
Vanessa Brooks |
| Edwards, Eric |
Pearl |
| Wong, Donna |
Nurse |
| Thomas, Carmen |
Senior Resident |
| Lee, Shannon |
Resident |
| Johnson, Kenny |
Heatseeking Dennis |
| Curtis, Clint |
Creepy Morgue Guy |
| Scott, Judson Earney |
Pallantine (as Judson Scott) |
| Liufau, Sidney S. |
Japanese Doorman (as Sidney Liufau) |
| Williams, Keith Leon |
Kam |
| Johnson, Andray |
Paramedic |
| Peluso, Stephen R. |
Paramedic |
| Aurelius, Marcus |
Pragmatic Policeman |
| Enos, III, John |
Blood Club Bouncer |
| Adams, Eboni 'Chrystal' |
Martial Arts Kid (as Eboni Adams) |
| Conway, Lyle |
Reichardt |
| White, III, Freeman |
Menacing Stud |
| DeVincentis, D. V. |
Vampire Underling |
| Salgado, Marcus |
Frost's Goon |
| McKnight, Jr., Esau |
Frost's Goon |
| Van Douglas, Erl |
Von Esper (as Erl) |
| Schulze, Matt |
Crease |
| Brown, Lennox |
Pleading Goon |
| Ocampo, Yvette |
Party Girl |
| Stepic, Irena |
Slavic Vampire Lord |
| Lano, Jenya |
Russian Woman |
| Outchaneichvili, Levani |
Russian Vampire (as Levani) |
| Baily, Richard 'Dr. ' |
Cardboard cut-out in Subway (uncredited) |
| Glorioso, Ryan |
Blood Bath Vampire (uncredited) |
| King, Ted |
Vampire at rave (uncredited) |
| Norrington, Stephen |
Vampire (uncredited) |
| Okamura, Gerald |
Vampire (uncredited) |
| Seeley, Carrie |
Woman in Elevator (uncredited) |
| Theriac, Beth |
Woman in Elevator (uncredited) |
