| Ôtsuka, Akio |
Thadeus (Japanese version) |
| Watson, Clayton |
Michael Karl Popper AKA The Kid (segment "Kid's Story") (voice) |
| Burress, Hedy |
Cis (segment "Program")/Yoko (segment "Beyond") (voice) |
| Carson, Terrence 'T. C. ' |
Clarence (voice) (as T.C. Carson) |
| Clarke, Melinda |
Alexa (segment "Matriculated") (voice) |
| D'Abo, Olivia |
Rox (segment "Matriculated") (voice) |
| Davis, Dane A. |
01 Versatran Spokesman (segment "The Second Renaissance, Part II") (voice) |
| DeMita, John |
Teacher (segment "Kid's Story") (voice) |
| Derryberry, Debi |
Kid (segment "The Second Renaissance, Part II") (voice) |
| Maggio, John Di |
Crew Man (segment "Final Flight of the Osiris")/Kaiser (segment "Program") |
| Fernández, Alex |
Tom (segment "World Record") (voice) |
| Fletcher, Jack |
Townsperson (segment "Beyond")/Sandro (segment "Matriculated") (voice) |
| Fletcher, Julia |
The Instructor (segments "The Second Renaissance, Parts I&II")/Narrator (segment "World Record")/Townsperson (segment "Beyond") (voice) |
| Ford, Bette |
Old Woman (segment "Final Flight of the Osiris") (voice) |
| Gomez, Rick |
Pilot (segment "Final Flight of the Osiris") (voice) |
| Kenny, Tom |
Operator (segment "Final Flight of the Osiris") (voice) |
| LaMarr, Phil |
Duo (segment "Program") (voice) |
| MacNeille, Tress |
Housewife/Kenny (segment "Beyond") (voice) |
| McKenzie, Matt |
Agent #1 (segment "World Record")/Agent (segments "Beyond" and "A Detective Story") (voice) |
| Moss, Carrie-Anne |
Trinity (segments "Kid's Story" and "A Detective Story") (voice) |
| Reeves, Keanu |
Neo (segment "Kid's Story") (voice) |
| Richardson, Kevin Michael |
Thadeus (segment "Final Flight of the Osiris")/Cop (segment "Kid's Story")/Agent #2 (segment "World Record") (voice) |
| Saulsberry, Rodney |
Chyron (segment "Matriculated") (voice) |
| Schultz, Dwight |
Townspeople, Policeman, Exterminators (segment "Beyond")/Nonaka (segment "Matriculated")/Additional voice (segments "The Second Renaissance, Part I&II") (voice) |
| Segall, Pamela |
Jue (segment "Final Flight of the Osiris")/Manabu (segment "Beyond") (voice) (as Pamela Adlon) |
| Smith, Allison |
Reporter (segment "World Record") (voice) |
| Soucie, Kath |
Pudgy/Masa/Sara (segment "Beyond") (voice) |
| Strong, Tara |
Crew Woman (segment "Final Flight of the Osiris")/Nurse (segment "World Record")/Misha (segment "Beyond") (voice) |
| Talley, Jill |
Mother/Additional voice (segments "The Second Renaissance, Parts I&II")/Townsperson (segment "Beyond") (voice) |
| Taylor, James Arnold |
Additional voice (segments "The Second Renaissance, Parts I&II)/Miscellaneous (segment "Kid's Story")/Ash (segment "A Detective Story")/Raul (segment "Matriculated") (voice) |
| Wesley, John |
Dan's Dad (segment "World Record") (voice) |
| Williams, Victor |
Dan (segment "World Record") (voice) |
