| Cage, Nicolas |
Charlie Kaufman/Donald Kaufman |
| Streep, Meryl |
Susan Orlean |
| Cooper, Chris |
John Laroche |
| Seymour, Cara |
Amelia Kavan |
| Swinton, Tilda |
Valerie Thomas |
| Livingston, Ron |
Marty Bowen |
| Cox, Brian |
Robert McKee |
| Gyllenhaal, Maggie |
Caroline Cunningham |
| Beaver, Jim |
Ranger Tony |
| Greer, Judy |
Alice the Waitress |
| Litefoot |
Russell (as G. Paul Davis) |
| Jones, Doug |
Augustus Margary |
| Tavare, Jay |
Matthew Osceola |
| Tobolowsky, Stephen |
Ranger Steve Neely (scenes deleted) |
| Willie, Roger |
Randy |
| Farmer, Gary |
Buster Baxley |
| Jason, Peter |
Defense Attorney |
| Itzin, Gregory |
Prosecutor |
| Hanson, Curtis |
Orlean's Husband |
| Baddoo, Agnes NaDene |
Orlean Dinner Guest (as Agnes Badoo) |
| Fortune, Paul |
Orlean Dinner Guest |
| Jasmin, Paul |
Orlean Dinner Guest |
| Love, Lisa |
Orlean Dinner Guest |
| Mogel, Wendy |
Orlean Dinner Guest |
| Russell, David O. |
Orlean Dinner Guest |
| Stephenson, Robert J. |
David (as Bob Stephenson) |
| Yerkes, Bob |
Charles Darwin |
| Court, Lynn |
Laroche's Dad |
| Fanter, Roger E. |
Laroche's Uncle |
| Gimpel, Sandra Lee |
Laroche's Mom (as Sandra Gimpel) |
| Colvett, Caron |
Laroche's Wife |
| Krask, Larry |
EMT |
| Etter, John |
McKee Lecture Attendee |
| Berrios, Ray |
Police Officer |
| Lenehan, Nancy |
Kaufman's Mother (voice) |
| Jonze, Spike |
Himself |
| Orlean, Susan |
Woman in supermarket (scenes deleted) |
| Acord, Lance |
Himself (uncredited) |
| Cusack, John |
Himself (uncredited) |
| Keener, Catherine |
Herself (uncredited) |
| Magnuson, Jake |
Cafe Customer (uncredited) |
| Malkovich, John |
Himself (uncredited) |
| Wallace, Rheagan |
Kim Canetti (uncredited) |
